AKR1C3-IN-9 | MedChemExpress (MCE)

AKR1C3-IN-9 产品活性：AKR1C3-IN-9 是醛酮还原酶 1C3 (AKR1C3) 的选择性抑制剂，IC50 为 8.92 nM。AKR1C3-IN-9 在耐药乳腺癌细胞系中显著逆转其对 Doxorubicin (HY-15142A) (DOX) 耐药性。 产品来源： https://www.medchemexpress.cn/akr1c3-in-9.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Aldose Reductase In Vitro: AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) results weak antiproliferative effect up to 100 μM in all three breast cancer cell lines (MDA-MB-231, MCF-7). AKR1C3-IN-9 (10 μM, 25 μM, and 50 μM; 72 h) synergistically inhibits the proliferation of MCF-7 cell with 10-50 μM DOX. AKR1C3-IN-9 (10 μM; 8 d) synergistically inhibits the proliferation, clonogenic survival of MCF-7/DOX cell line, thus restores the sensitivity to DOX. 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Breast Cancer Compound Library | Glucose Metabolism Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Anti-Drug-Resistant Compound Library | Bioactive Compound Library Max | Isoliquiritigenin | Epalrestat | Poliumoside | Fidarestat | Soyasaponin Bb | Tolrestat | Ponalrestat | Sorbinil | Calceolarioside B | Imirestat | Alrestatin | Caficrestat | Exisulind | Zopolrestat | Ganoderic acid C2 | Ranirestat | Quercetin 3-gentiobioside | β-Glucogallin | Ganoderic acid C6 | Govorestat | Lidorestat | ALR2-IN-1 | Risarestat | Soyasaponin Ba | Zenarestat | 5-Bromo-3-phenyl salicylic acid | 6,7-Dihydroxy-4-coumarinylacetic acid | 6-Hydroxyluteolin | 6-Methoxytricin | AKR1B10-IN-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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