Product Specification
Alternative Name: 5-Amino-[(N-2,5-dihydroxybenzyl)-N'-2-hydroxybenzyl]salicylic acid, RG14355
Formula: C21H19NO6
MW: 381.4
Purity: ≥98%
Appearance: Off-white to tan solid.
CAS: 125697-92-9
Solubility: Soluble in DMSO or ethanol.
Shipping: AMBIENT
Long Term Storage: +4°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Prepare solutions fresh daily.
Handling: Protect from oxygen.
Replaces Prod. #: ALX-350-007
Cell permeable tyrosine kinase inhibitor with little effect on cAMP-dependent protein kinase (PKA) or protein kinase C (PKC). Potent and selective inhibitor of the EGF receptor tyrosine kinase (IC50=11nM). Binds to a site on the kinase which is distinct from the ATP and peptide substrate binding sites. Inhibits EGF-induced proliferation of cultured human myometrial smooth muscle cells and suppresses VEGF-induced angiogenesis in rats. Effective at 10µM in cultured leech neurons. Also inhibits NMDA-stimulated cGMP production.