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BML-EI373-0010 10 mg  INQUIRE   ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 250nM respectively). Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail.
Product Specification
Formula: C29H31N5O4
MW: 513.6
Purity: ≥98% (TLC)
CAS: 331771-20-1
Solubility: Soluble in DMSO (25 mg/ml).
Shipping: AMBIENT
Long Term Storage: +20°C
Use/Stability: Store solutions at -20°C for up to 3 months.