BML-PI129-0010 10 mg
BML-PI129-0002 2 mg
Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Inhibits the chymotrypsin-like activity of the 20S proteasome in a non-competitive manner. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells. Displays anti-inflammatory activity in vivo. Antioxidant. Inhibitor of farnesyltransferase and geranylgeranyltransferase I.A negatve control analog is available (Prod. No. BML-L122).
Product Specification
Alternative Name: [3R-(3α, 5aβ,6β,10aα)]-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epi-dithiopyrazino[1,2-a]indole-1,4-dione
Formula: C13H14N2O4S2
MW: 326.4
Purity: ≥98% (TLC)
Appearance: White solid.
CAS: 67-99-2
MI: 14: 4441
RTECS: KB4725000
Source/Host: Isolated from Gladiocladium fimbriatum.
Solubility: Soluble in DMSO or methanol (10mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stock solutions are stable for up to 3 months when stored at -20°C.
Hazard: TOXIC.
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