R406 (free base)-分析测试百科网

R406 (free base)

面议

分子式 C22H23FN6O5 分子量470.45 属性溶解性 DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C //decorateTable('pro

400-6699-117 转1000

耗材描述

溶解性	DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

产品介绍	R406 (free base)是一种有效的Syk抑制剂,IC50为41 nM,强效抑制Syk而不能抑制Lyn,对Flt3作用效果低5倍。
备注	R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 2.
生化机理	R406(free base) is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM.
别名	R-406; 6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-2H-吡啶并[3,2-b]-1,4-恶嗪-3(4H)-酮;R-406;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one