| 应用 |
A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4. |
| 产品介绍 |
BGJ398 (NVP-BGJ398)是一种有效的，选择性的FGFR抑制剂，作用于FGFR1/2/3，IC50为0.9 nM/1.4 nM/1 nM，作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上，对Abl， Fyn， Kit， Lck， Lyn和Yes几乎没有抑制活性。Phase 2。 |
| 备注 |
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. |
| 生化机理 |
BGJ398 is a potent and selective fibroblast growth factor receptor family inhibitor for Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4. |
| 别名 |
BGJ-398;BGJ 398;NVP BGJ398;3-(2,6-二氯-3,5-二甲氧基苯基)-1-[6-[[4-(4-乙基哌嗪-1-基)苯基]氨基]嘧啶-4-基]-1-甲基脲;3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;Infigratinib |
