| 生化机理 |
BI6727 is an ATP-competitive Plk1/2/3 inhibitor from the dihydropteridinone family with IC50 values of 5 nM and 56 nM, respectively. BI6727 inhibits the proliferation of multiple cell lines derived from various cancer tissues, including HCT116, NCI-H460, BRO, GRANTA-519, HL-60, THP-1, and Raji cells with EC50 of 23 nM, 21 nM, 11 nM, 15 nM, 32 nM, 36 nM, and 37 nM, respectively. BI6727 displays potent inhibitory activity against neuroblastoma tumor-initiating cells (NB TIC) with EC50 of 21 nM. |
| 别名 |
BI 6727;BI-6727;BI6727; N-(反式-4-(4-(环丙基甲基)-1-哌嗪基)环己基)-4-(((7R)-7-乙基-5,6,7,8-四氢-5-甲基-8-异丙基-6-氧代-2-蝶啶基)氨基)-3-甲氧基苯甲酰胺;;BI 6727;BI-6727;BI6727; n-(trans-4-(4-(cyclopropylmethyl)-1-piperazinyl)cyclohexyl)-4-(((7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl)amino)-3-methoxybenzamide |
