SU5416
面议
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分子式 C15H14N2O 分子量238.28 MDL号 MFCD01940922 PubChem编号 24278606 属性 熔点 221-222 °C 溶解性 Soluble in DMSO (5 mg/ml), and ethanol
| 货号 | CAS号 | 操作 |
|---|---|---|
| S125835-50mg | 204005-46-9 | 询底价 |
| S125835-10mg | 204005-46-9 | 询底价 |
耗材描述
- 分子式 C15H14N2O
- 分子量238.28
- MDL号 MFCD01940922
- PubChem编号 24278606
属性
| 熔点 | 221-222 °C |
| 溶解性 | Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | It was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain，and study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension. |
| 产品介绍 | Semaxanib (SU5416)是VEGFR(Flk-1/KDR)抑制剂，IC50为1.23 μM，比对PDGFRβ的抑制性高20倍，对EGFR，InsR和FGFR无活性。 |
| 生化机理 | VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies suggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways. |
| 别名 | SU-5416; 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮;Semaxinib;SU-5416;VEGFR2 Kinase Inhibitor III; 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one |
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