耗材描述

• 分子式 C₁₆H₂₅N₃O₃
• 分子量307.39
• Beilstein号
• EC号
• MDL号 MFCD03453554
• PubChem编号

属性

溶解性	Soluble in DMSO (62 mg/ml at 25 °C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
存贮条件	储存温度2-8℃

描述

应用	A potent HDAC inhibitor with IC50 of 100.
产品介绍	M344是一种有效的HDAC抑制剂，IC50为100 nM，可以诱导细胞分化。
备注	M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
生化机理	M344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.
别名	4-二甲基氨基-N-(6-羟基氨基甲酰己基)苯甲酰胺;4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺;M 344;M-344;D 237;MS 344;4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide

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