| 应用 |
An inhibitor of Topo I. |
| 产品介绍 |
Irinotecan HCl Trihydrate通过抑制Topoisomerase 1（拓扑异构酶1）而防止DNA解链。 |
| 备注 |
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
| 生化机理 |
Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line. |
| 别名 |
三水盐酸伊立替康;盐酸伊立替康三水合物;伊立替康盐酸盐三水合物;PNU-101440E;CPT-11 Trihydrate;Irinotecan Hydrochloride Trihydrate;(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinolin-9-yl ester monohydrochloride trihydrate Irinotecan monohydrochloride trihydrate |
