Voriconazole
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分子式 C16H14F3N5O 分子量349.31 Beilstein号 EC号 MDL号 MFCD00905717 PubChem编号 属性 沸点 ~508.6° C at 760 mmHg 熔点 128-134° C 旋光率 -58.0
| 货号 | CAS号 | 操作 |
|---|---|---|
| V129745-500mg | 137234-62-9 | 询底价 |
| V129745-5g | 137234-62-9 | 询底价 |
| V129745-50mg | 137234-62-9 | 询底价 |
| V129745-250mg | 137234-62-9 | 询底价 |
| V129745-1g | 137234-62-9 | 询底价 |
耗材描述
- 分子式 C16H14F3N5O
- 分子量349.31
- Beilstein号
- EC号
- MDL号 MFCD00905717
- PubChem编号
属性
| 沸点 | ~508.6° C at 760 mmHg |
| 熔点 | 128-134° C |
| 旋光率 | -58.0 to -62.0 deg(C=1, MeOH) |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
描述
| 应用 | An antifungal CYP2C9 inhibitor |
| 产品介绍 | Voriconazole (伏立康唑; UK-109496) 是第二代三唑类抗真菌化合物，可作用于严重的真菌感染。 |
| 备注 | Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. |
| 生化机理 | Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease |
| 别名 | 伏立康唑; (2R,3S)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇;Vfend;UK-109496; 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
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