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分子式 C18H19ClN4 分子量326.82 Beilstein号 EC号 MDL号 MFCD00153785 PubChem编号 24277892 属性 熔点 182-184℃ 溶解性 DMSO 65 mg/mL Water <
| 货号 | CAS号 | 操作 |
|---|---|---|
| C126883-100g | 5786-21-0 | 询底价 |
| C126883-100mg | 5786-21-0 | 询底价 |
| C126883-1g | 5786-21-0 | 询底价 |
| C126883-25g | 5786-21-0 | 询底价 |
| C126883-5g | 5786-21-0 | 询底价 |
耗材描述
- 分子式 C18H19ClN4
- 分子量326.82
- Beilstein号
- EC号
- MDL号 MFCD00153785
- PubChem编号 24277892
属性
| 熔点 | 182-184℃ |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors. |
| 产品介绍 | Clozapine 是一种有效的5-HT1C受体拮抗剂，作用于5-HT刺激的磷酸肌醇水解，IC50为110 nM。 |
| 备注 | Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| 生化机理 | Clozapine is atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively). |
| 别名 | 8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
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