耗材描述
- 分子式 C18H19ClN4
- 分子量326.82
- Beilstein号
- EC号
- MDL号 MFCD00153785
- PubChem编号 24277892
属性
熔点 | 182-184℃ |
溶解性 |
|
存贮条件 | 储存温度2-8℃ |
描述
应用 | Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors. |
产品介绍 | Clozapine 是一种有效的5-HT1C受体拮抗剂,作用于5-HT刺激的磷酸肌醇水解,IC50为110 nM。 |
备注 | Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
生化机理 | Clozapine is atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively). |
别名 | 8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
Reaxys-RN | 764984 |
标识符号 |
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信号词 | Danger |
危害声明 | H301-H341-H361 |
警示性声明 | P281-P301 + P310 |
RTECS | HP1750000 |
WGK德国 | 3 |
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