耗材描述

• 分子式 C₂₂H₂₄ClN₃O·HCl
• 分子量418.36

属性

敏感性	对热敏感
溶解性	Soluble in water (25 mg/mL), DMSO (>10 mg/mL), and ethanol.
存贮条件	储存温度-20°C

描述

应用	An H1-receptor antagonist with antiallergic effects and disrupts TNF alpha activity.
产品介绍	Azelastine HCl是有效的，第二代选择性组胺拮抗剂。
备注	Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist.
生化机理	Azelastine HCl is an Histamine H1 Receptor (H1-receptor) antagonist, with antiallergic effects related to histamine antagonism, and further antiallergic and antiinflammatory effects unrelated to H1-receptor binding. Azelastine is shown to block secretion of IL-6, IL-8, and TNF alpha from mast cells by inhibiting NF-κB activation. Azelastine HCl is an activator of NF κ B.
别名	4-(4-氯苄基)-2-(1-甲基氮杂卓-4-基)-1-酞嗪酮盐酸盐;氮?斯汀盐酸盐 ;盐酸氮?斯汀;Astelin;Optivar;4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)-1-phthalazinone Hydrochloride;Allergodil; Rhinolast; Optilas

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