A129214-1gAzelastine HCl
面议
- 阿拉丁
- 生产商
- A129214-1g
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C22H24ClN3O·HCl
- 分子量418.36
属性
敏感性 | 对热敏感 |
溶解性 | Soluble in water (25 mg/mL), DMSO (>10 mg/mL), and ethanol. |
存贮条件 | 储存温度-20°C |
描述
应用 | An H1-receptor antagonist with antiallergic effects and disrupts TNF alpha activity. |
产品介绍 | Azelastine HCl是有效的,第二代选择性组胺拮抗剂。 |
备注 | Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist. |
生化机理 | Azelastine HCl is an Histamine H1 Receptor (H1-receptor) antagonist, with antiallergic effects related to histamine antagonism, and further antiallergic and antiinflammatory effects unrelated to H1-receptor binding. Azelastine is shown to block secretion of IL-6, IL-8, and TNF alpha from mast cells by inhibiting NF-κB activation. Azelastine HCl is an activator of NF κ B. |
别名 | 4-(4-氯苄基)-2-(1-甲基氮杂卓-4-基)-1-酞嗪酮盐酸盐;氮?斯汀盐酸盐 ;盐酸氮?斯汀;Astelin;Optivar;4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)-1-phthalazinone Hydrochloride;Allergodil; Rhinolast; Optilas |
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