耗材描述

• 分子式 C₉H₇ClFN₅O₂
• 分子量271.64
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

沸点	~318.6 °C at 760 mmHg
熔点	154.74 °C
折光率	1.72
溶解性	25°C: DMSO
存贮条件	储存温度-20°C
密度	1.8000

描述

应用	A competitive indoleamine 2,3-dioxygenase inhibitor
产品介绍	IDO5L是高活性IDO1抑制剂，IC50为67 nM。
生化机理	In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM. In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells.
别名	IDO5L;4-氨基-N-(3-氯-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒;;IDO5L;indoleamine-2,3-dioxygenase inhibitor；4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide

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