耗材描述

• 分子式 C₁₆H₁₇N₃O₄S
• 分子量347.39
• Beilstein号
• EC号
• MDL号 MFCD22580416
• PubChem编号

属性

溶解性	25°C: DMSO 69 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

应用	An epigenetic chemical probe.
产品介绍	PFI-1能阻断BET BRDs与H3、H4乙酰化组蛋白尾巴的相互作用。
生化机理	The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). For full characterization details, please visit the PFI-1 probe summary on the Structural Genomics Consortium (SGC) website.
别名	PFI-1；PFI 1;PFI1；2-甲氧基-N-(3-甲基-2-氧代-1,2,3,4-四氢喹唑啉-6-基)苯磺酰胺;PFI-1；PFI 1;PFI1；PF-06405761；2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

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