GW3965 HCl
面议
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分子式 C33H31ClF3NO3.HCl 分子量618.51 Beilstein号 EC号 MDL号 MFCD08276920 PubChem编号 24724494 属性 溶解性 DMSO 124 mg/mL Water <1 mg
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129708-100mg | 405911-17-3 | 询底价 |
| G129708-10mg | 405911-17-3 | 询底价 |
| G129708-1mg | 405911-17-3 | 询底价 |
| G129708-50mg | 405911-17-3 | 询底价 |
| G129708-5mg | 405911-17-3 | 询底价 |
耗材描述
- 分子式 C33H31ClF3NO3.HCl
- 分子量618.51
- Beilstein号
- EC号
- MDL号 MFCD08276920
- PubChem编号 24724494
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | GW3965 hydrochloride |
| 备注 | GW3965 is a potent, selective LXRagonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
| 生化机理 | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. |
| 别名 | ;N/A; GW3965 hydrochloride; 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride |
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