G129708-100mg&GW3965 HCl
面议
- 阿拉丁
- 生产商
- G129708-100mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C33H31ClF3NO3.HCl
- 分子量618.51
- Beilstein号
- EC号
- MDL号 MFCD08276920
- PubChem编号 24724494
属性
溶解性 |
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存贮条件 | 储存温度-20°C |
描述
产品介绍 | GW3965 hydrochloride |
备注 | GW3965 is a potent, selective LXRagonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
生化机理 | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. |
别名 | ;N/A; GW3965 hydrochloride; 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride |
标识符号 |
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信号词 | Danger |
危害声明 | H302-H318-H413 |
警示性声明 | P280-P305 + P351 + P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
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