Clotrimazole
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分子式 C22H17ClN2 分子量344.84 EC号 245-764-8 MDL号 MFCD00057220 PubChem编号 24278327 属性 熔点 141-149° C 溶解性 Soluble in DMSO (25 mM)
| 货号 | CAS号 | 操作 |
|---|---|---|
| C129965-5g | 23593-75-1 | 询底价 |
| C129965-100g | 23593-75-1 | 询底价 |
| C129965-250g | 23593-75-1 | 询底价 |
| C129965-25g | 23593-75-1 | 询底价 |
耗材描述
- 分子式 C22H17ClN2
- 分子量344.84
- EC号 245-764-8
- MDL号 MFCD00057220
- PubChem编号 24278327
属性
| 熔点 | 141-149° C |
| 溶解性 | Soluble in DMSO (25 mM), chloroform (50 mg/ml), DMF, ethyl acetate, ethanol, methanol, and acetone. |
描述
| 应用 | An antifungal compound and CYP inhibitor |
| 产品介绍 | Clotrimazole是一种合成的抗真菌药物，是imidazole的广谱衍生物 |
| 备注 | Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole. |
| 生化机理 | Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1. |
| 别名 | 1-[(2-氯苯基)二苯甲基]-1H-咪唑;三苯氯甲咪唑;氯苯甲咪唑;克霉唑;1-[(2-氯苯基)二苯甲基]咪唑;1-(2-氯三苯甲基)咪唑;1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole;1-(o-Chlorotrityl)imidazole ;1-[(2-Chlorophenyl)diphenylmethyl]imidazole ;1-(2-Chlorotrityl)imidazole |
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