耗材描述

• 分子式 C₁₅H₁₃N₃S
• 分子量267.35
• MDL号 MFCD01121974

属性

沸点	444.82° C
熔点	174.66° C
折光率	1.67
溶解性	DMSO 53 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
存贮条件	储存温度-20°C
密度	1.2600

描述

应用	STF-62247 may be used as positive control in autophagy inducing cell signaling studies.
产品介绍	STF-62247是一个TGN抑制剂，在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。
备注	STF-62247 shows selectivtoxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
生化机理	Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). Selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 μM in RCC4 and RCC4/VHL killing, respectively) and in mice. Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
别名	STF62247;STF 62247;N-(3-甲基苯基)-4-(4-吡啶基)-1,3-噻唑-2-胺;STF62247;STF 62247;N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

标识符号	GHS07
信号词	Warning
危害声明	H302-H319
警示性声明	P305 + P351 + P338
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
WGK德国	2

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