PF-8380-分析测试百科网

PF-8380

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：4
近期咨询：1

分子式 C22H21Cl2N3O5 分子量478.33 属性溶解性 Soluble in DMSO (100 mM), water (slightly), DMF (~5 mg/ml), and DMF:PBS (pH 7.2)(1:6)

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
P126449-100mg	1144035-53-9	询底价
P126449-5mg	1144035-53-9	询底价
P126449-10mg	1144035-53-9	询底价
P126449-50mg	1144035-53-9	询底价

耗材描述

分子式 C₂₂H₂₁Cl₂N₃O₅
分子量478.33

属性

溶解性	Soluble in DMSO (100 mM), water (slightly), DMF (~5 mg/ml), and DMF:PBS (pH 7.2)(1:6) (~0.14 mg/ml).
存贮条件	储存温度-20°C

描述

应用	A substrate competitive and tight-binding inhibitor of autotaxin.
产品介绍	PF-8380是高活性的autotaxin特异性抑制剂，IC50为2.8 nM。
生化机理	PF-8380 is an orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}.
别名	PF 8380;PF8380; 4-[3-氧代-3-(2-氧代-2,3-二氢苯并恶唑-6-基)丙基]哌嗪-1-羧酸 3,5-二氯苄酯;PF 8380;PF8380;6-(3-(piperazin-1-yl)propanoyl)benzo(d)oxazol-2(3H)-one;4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic acid (3,5-dichlorophenyl)methyl ester; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

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