Dorsomorphin 2HCl-分析测试百科网

Dorsomorphin 2HCl

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：0

分子式 C24H25N5O·2HCl 分子量472.41 Beilstein号 EC号 MDL号 PubChem编号属性溶解性 Soluble in water (100 mM), and DMSO (20 mM). 存贮条件储存温度

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上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
D129758-50mg	1219168-18-9	询底价
D129758-5mg	1219168-18-9	询底价
D129758-10mg	1219168-18-9	询底价

耗材描述

分子式 C₂₄H₂₅N₅O·2HCl
分子量472.41
Beilstein号
EC号
MDL号
PubChem编号

属性

溶解性	Soluble in water (100 mM), and DMSO (20 mM).
存贮条件	储存温度-20°C

描述

应用	A potent and selective AMPK inhibitor.
产品介绍	Dorsomorphin 2HCl是一种有效的，可逆的AMPK选择性抑制剂，Ki为109 nM，对一些结构相关的激酶，包括ZAPK， SYK， PKCθ， PKA和JAK3没有显著的抑制作用。同时抑制了BMP一型受体作用。
备注	Dorsomorphin is a potent, reversible, selective AMPK inhibitor with K_i of 109 nM, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3.
生化机理	Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thought to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available .
别名	BML-275;6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-a]嘧啶二盐酸盐;BML-275;6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2);Compound C dihydrochloride; BML275 dihydrochloride; BML 275 dihydrochloride

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