Ridaforolimus (Deforolimus, MK-8669)-分析测试百科网

Ridaforolimus (Deforolimus, MK-8669)

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：4
近期咨询：1

分子式 C53H84NO14P 分子量990.21 Beilstein号 EC号 MDL号 PubChem编号属性溶解性 DMSO ≥196mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 存贮

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
D126066-100mg	572924-54-0	询底价
D126066-10mg	572924-54-0	询底价
D126066-50mg	572924-54-0	询底价
D126066-5mg	572924-54-0	询底价

耗材描述

分子式 C₅₃H₈₄NO₁₄P
分子量990.21
Beilstein号
EC号
MDL号
PubChem编号

属性

溶解性	DMSO ≥196mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件	储存温度-20°C

描述

应用	A selective FRAP (mTOR) inhibitor
产品介绍	Ridaforolimus (Deforolimus, MK-8669)是一种选择性的mTOR抑制剂，IC50为0.2 nM；对mTOR信号通路的抑制作用及与FKBP12结合能力和Rapamycin接近。
备注	Ridaforolimus (Deforolimus) is a selective mTOR inhibitor with IC50 of 0.2 nM; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin.
生化机理	Deforolimus is a selective FRAP (mTOR) inhibitor (IC50 of 0.2 nM), used to treat HT-1080 cells induces a dose-dependent inhibition of both S6 and 4E-BP1 phosphorylation, with IC50 of 0.2 nM and 5.6 nM, respectively, and leads to a decrease in cell size, an increase in the proportion of cells in the G1 phase of the cell cycle, and inhibition of glucose uptake. Ridaforolimus shows antiproliferative activity a variety of cell lines with EC50 of 0.2-2.3 nM. Ridaforolimus is a potent and selective inhibitor of VEGF production in a dose-dependent manner. Ridaforolimus treatment causes growth suppression in human NSCLC cell lines with IC30 values of 2.45-8.83 nM, with the exception of H157 with IC30 of >20 nM. Ridaforolimus treatment causes dephosphorylation of p70S6KThr389 in A549, H1703 and H157 cells, except H1666 that may express a resistant variant of mTORC1, and causes increased phosphorylation of pAKTser473 and pAKTThr308 in A549 and H1703 cells.
别名	AP23573;药雷帕霉素;MK 8669; 42-(二甲基亚膦酰)雷帕霉素;AP23573; MK-8669; Ridaforolimus; AP 23573; MK 8669; AP-23573; MK8669;42-(Dimethylphosphinate)rapamycin

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