WYE-125132 (WYE-132)-分析测试百科网

WYE-125132 (WYE-132)

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子式 C27H33N7O4 分子量519.61 属性溶解性 DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C 密度 1.6000 //decorate

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
W128041-100mg	1144068-46-1	询底价
W128041-25mg	1144068-46-1	询底价
W128041-5mg	1144068-46-1	询底价

耗材描述

分子式 C₂₇H₃₃N₇O₄
分子量519.61

属性

溶解性	DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1.6000

描述

应用	A highly potent, ATP-competitive, and specific mTOR kinase inhibitor
产品介绍	WYE-125132是ATP竞争性mTOR选择性抑制剂，IC50为0.19 nM，对PI3Ks及其相关的hSMG1和ATR抑制性较弱。
生化机理	WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.
别名	WYE-125132；WYE 125132; WYE125132；WYE 125132; N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-d]嘧啶-6-基]苯基]-N'-甲基脲;WYE-125132；WYE 125132;WYE125132；N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea

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