TDZD-8
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分子式 C10H10N2O2S 分子量222.26 MDL号 MFCD04973552 属性 溶解性 25°C: DMSO 存贮条件 储存温度-20°C //decorateTable('product-attribute-specs-ta
| 货号 | CAS号 | 操作 |
|---|---|---|
| T126722-5mg | 327036-89-5 | 询底价 |
| T126722-100mg | 327036-89-5 | 询底价 |
| T126722-25mg | 327036-89-5 | 询底价 |
耗材描述
- 分子式 C10H10N2O2S
- 分子量222.26
- MDL号 MFCD04973552
属性
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb. |
| 产品介绍 | TDZD-8(NP 01139)是thiadiazolidinone的衍生物，是非ATP竞争性GSK-3β抑制剂，IC50为2 μM，对Cdk-1/cyclin B，CK-II，PKA和PKC无活性。 |
| 生化机理 | TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β. |
| 别名 | TDZD 8;TDZD8;NP 01139;4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮;TDZD 8;TDZD8;GSK-3β Inhibitor I;NP 01139;4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
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