T126722-5mgTDZD-8
面议
- 阿拉丁
- 生产商
- T126722-5mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C10H10N2O2S
- 分子量222.26
- MDL号 MFCD04973552
属性
溶解性 | 25°C: DMSO |
存贮条件 | 储存温度-20°C |
描述
应用 | TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb. |
产品介绍 | TDZD-8(NP 01139)是thiadiazolidinone的衍生物,是非ATP竞争性GSK-3β抑制剂,IC50为2 μM,对Cdk-1/cyclin B,CK-II,PKA和PKC无活性。 |
生化机理 | TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β. |
别名 | TDZD 8;TDZD8;NP 01139;4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮;TDZD 8;TDZD8;GSK-3β Inhibitor I;NP 01139;4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
标识符号 |
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信号词 | Danger |
危害声明 | H334 |
警示性声明 | P261-P342 + P311 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
WGK德国 | 3 |
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