SB216763
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
- 3
- 1
分子式 C19H12N2O2Cl2 分子量371.22 MDL号 MFCD09753369 PubChem编号 24278616 属性 溶解性 DMSO 23 mg/mL Water <1 mg/mL Ethanol <1 mg
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129716-5mg | 280744-09-4 | 询底价 |
| S129716-50mg | 280744-09-4 | 询底价 |
| S129716-10mg | 280744-09-4 | 询底价 |
耗材描述
- 分子式 C19H12N2O2Cl2
- 分子量371.22
- MDL号 MFCD09753369
- PubChem编号 24278616
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | SB 216763 |
| 合法信息 | Sold for only research purposes |
| 备注 | SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. |
| 生化机理 |
SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. SB 216763 also reduces pulmonary inflammation and fibrosis in a mouse model. |
| 别名 | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
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