S129716-5mgSB216763
面议
- 阿拉丁
- 生产商
- S129716-5mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C19H12N2O2Cl2
- 分子量371.22
- MDL号 MFCD09753369
- PubChem编号 24278616
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | SB 216763 |
合法信息 | Sold for only research purposes |
备注 | SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. |
生化机理 |
SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. SB 216763 also reduces pulmonary inflammation and fibrosis in a mouse model. |
别名 | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
标识符号 |
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信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
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