Fenretinide
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分子式 C26H33NO2 分子量391.55 MDL号 MFCD00792674 PubChem编号 24278472 属性 敏感性 对热和空气敏感 溶解性 Soluble in DMSO (25 mg/ml), ethanol (25
| 货号 | CAS号 | 操作 |
|---|---|---|
| F126912-100mg | 65646-68-6 | 询底价 |
| F126912-250mg | 65646-68-6 | 询底价 |
| F126912-25mg | 65646-68-6 | 询底价 |
| F126912-50mg | 65646-68-6 | 询底价 |
| F126912-10mg | 65646-68-6 | 询底价 |
耗材描述
- 分子式 C26H33NO2
- 分子量391.55
- MDL号 MFCD00792674
- PubChem编号 24278472
属性
| 敏感性 | 对热和空气敏感 |
| 溶解性 | Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml)), chloroform, and acetone (easily soluble). |
| 存贮条件 | 储存温度 -20°C,充氩保存 |
描述
| 应用 | An agonist displaying activity at retinoid receptors |
| 产品介绍 | Fenretinide (4-HPR)是合成的维甲酸衍生物，能结合维甲酸受体（RAR）。 |
| 生化机理 | 4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies suggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis. |
| 别名 | 4-HPR;全反式-N-(4-羟苯基)维甲酸;维甲酸对羟基苯胺;芬维A胺;维甲酰酚胺;4-HPR; (4-Hydroxyphenyl)retinamide; N-(4-Hydroxyphenyl)retinamide;all-trans-N-(4-Hydroxyphenyl)retinamide;Retinoic acid p-hydroxyanilide;4-Hydroxyphenylretinamide |
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