Crenolanib (CP-868596)-分析测试百科网

Crenolanib (CP-868596)

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：0

分子式 C26H29N5O2 分子量443.54 属性溶解性 DMSO 89 mg/mL Water <1 mg/mL Ethanol 7 mg/mL 存贮条件储存温度-20°C //decorateTable('product-

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
C127776-50mg	670220-88-9	询底价
C127776-5mg	670220-88-9	询底价
C127776-10mg	670220-88-9	询底价

耗材描述

分子式 C₂₆H₂₉N₅O₂
分子量443.54

属性

溶解性	DMSO 89 mg/mL Water <1 mg/mL Ethanol 7 mg/mL
存贮条件	储存温度-20°C

描述

备注	Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2,
生化机理	Crenolanib (CP-868569) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, respectively. In addition,Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase with an IC50 of 1 nM.
别名	1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine;1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine

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