Ochratoxin A
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分子式 C20H18ClNO6 分子量403.81 Beilstein号 8169012 EC号 MDL号 MFCD00078079 PubChem编号 24870560 属性 敏感性 对湿度敏感 溶解性 Soluble in chloro
| 货号 | CAS号 | 操作 |
|---|---|---|
| O102402-1mg | 303-47-9 | 询底价 |
| O102402-5mg | 303-47-9 | 询底价 |
| O102402-25mg | 303-47-9 | 询底价 |
耗材描述
- 分子式 C20H18ClNO6
- 分子量403.81
- Beilstein号 8169012
- EC号
- MDL号 MFCD00078079
- PubChem编号 24870560
属性
| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). Insoluble in water., Soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). Insoluble in water. |
| 存贮条件 | 储存温度-20℃ |
| 密度 | 1.4250 |
描述
| 应用 | A nephrotoxic mycotoxin inhibitor of phenylalanyl-tRNA synthetases. |
| 产品介绍 | Ochratoxin A is a mycotoxin isolated from the Aspergillus ochraceus mold, a common fungal presence on moldy food. Ochratoxin A demonstrates nephrotoxicity and teratogenesis in animals, and shows inhibition of bacterial, yeast, and liver FARSL (phenylalanyl-tRNA synthetases) competitive with phenylalanine. As these activities are partially attenuated by phenylalanine, Ochratoxin A is suggested to produce its effects through interacting with proteins that recognize phenylalanine as a substrate, and has been demonstrated to inhibit PAH (phenylalanine hydroxylase). Derivatives of Ochratoxin A with other amino acid moieties substituted for the phenylalanine-mimic portion of the molecule demonstrate inhibition of the aminoacyl tRNA synthetases respective to those amino acids. Ochratoxin A is described to enhance lipid peroxidation and also present DNA single strand breaks, both suggesting oxidative damage as a partial mediator of Ochratoxin A cellular effects, and EPR spectroscopy with a spin trap agent identified the production of hydroxyl radicals by Ochratoxin A in the presence of NADPH. The nephrotoxic effects of Ochratoxin A are shown to be prevented by SOD (superoxide dismutase) and catalase, further indicating oxidative damage as the mediator of Ochratoxin A toxicity. Ochratoxin A is also demonstrated to increase ATP-dependent Ca2+ pump activity in renal cortex endoplasmic reticulum. |
| 生化机理 | Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity. |
| 别名 | N-[(3R)-(5-氯-8-羟基-3-甲基-1-氧代-7-苯并二氢异吡喃基)羰基]-L-苯丙氨酸;N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine |
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