Trehalose 6,6′-dimycolate-分析测试百科网

Trehalose 6,6′-dimycolate

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：1
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分子式 C172O15H328 分子量2,636.47 Beilstein号 EC号 MDL号 MFCD00081533 PubChem编号属性存贮条件储存温度-20°C //decorateTable('product-attrib

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
T120976-1mg	61512-20-7	询底价

耗材描述

分子式 C₁₇₂O₁₅H₃₂₈
分子量2,636.47
Beilstein号
EC号
MDL号 MFCD00081533
PubChem编号

属性

存贮条件	储存温度-20°C

描述

应用	A glycolipid that induces macrophages to release inflammatory cytokines independent of TLR2 or TLR4
产品介绍	To stimulate mouse bone marrow-derived macrophages, Cord Factor was suspended at a concentration of 0.2mg/ml in hexane. Of the resulting solution 1 or 10μg/well were layered in 96-well tissue culture plates and the solvent completely evaporated. Control wells were layered with solvent without Cord Factor and also incubated at 37°C. To this layer of Cord Factor, bone marrow-derived macrophages were added in 100μl of medium and incubated at 37°C for 24 hours before activation e.g. TNF-α production was measured in the supernatant. In vivo pulmonary granuloma formation in mice can be induced by 10μg Cord Factor per mouse applied i.v. in a water/oil/water emulsion.
生化机理	Cord factor is a glycolipid released from Mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids. It activates macrophages to release inflammatory cytokines and induces thymic atrophy and granuloma formation in lung and other organs. It is responsible for the necrosis and cavitation observed in secondary tuberculosis.
别名	Cord Factor;Cord Factor

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