cholest-(25R)-5-ene-3β,27-diol-分析测试百科网

cholest-(25R)-5-ene-3β,27-diol

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：2
近期咨询：1

分子式 C27H46O2 分子量402.65300 属性溶解性 Soluble in chloroform. Insoluble in water. 存贮条件储存温度-20°C //decorateTable('product-attr

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
C130177-5mg	20380-11-4	询底价
C130177-25mg	20380-11-4	询底价

耗材描述

分子式 C₂₇H₄₆O₂
分子量402.65300

属性

溶解性	Soluble in chloroform. Insoluble in water.
存贮条件	储存温度-20°C

描述

应用	An oxysterol with cholesterol oxidation metabolite properties.
产品介绍	27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β.
别名	27-羟基胆固醇;5,25R-胆甾烯-3beta,26-二醇；;27-hydroxycholesterol;5,25R-Cholesten-3beta,26-diol;cholest-5-ene-3β,27-diol, (25R);27-hydroxycholesterol(25R);(25R)-Cholest-5-ene-3β,26-diol

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