6-硫鸟嘌呤
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分子式 C5H5N5S 分子量167.19 Beilstein号 157765 EC号 205-827-2 MDL号 MFCD00233553 PubChem编号 24890748 属性 熔点 360°C //decorateTable('
| 货号 | CAS号 | 操作 |
|---|---|---|
| T106639-1g | 154-42-7 | 询底价 |
| T106639-25g | 154-42-7 | 询底价 |
| T106639-5g | 154-42-7 | 询底价 |
耗材描述
- 分子式 C5H5N5S
- 分子量167.19
- Beilstein号 157765
- EC号 205-827-2
- MDL号 MFCD00233553
- PubChem编号 24890748
属性
| 熔点 | 360°C |
描述
| 应用 | 抗肿瘤。 |
| 产品介绍 | 6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein. |
| 生化机理 |
Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides. Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia. |
| 别名 | 2-氨基-6-巯基嘌呤; 6-硫代鸟嘌呤; 2-氨基-6-巯嘌呤;2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol; 6-Mercaptoguanine |
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