内皮素-1-分析测试百科网

内皮素-1

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品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：2
近期咨询：1

分子式 C109H159N25O32S5 分子量2491.90 MDL号 MFCD00133305 PubChem编号 24894656 属性存贮条件储存温度 -20°C 密度 1.1300 //decorateTable('produ

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
E101621-5mg	117399-94-7	询底价
E101621-1mg	117399-94-7	询底价

耗材描述

分子式 C₁₀₉H₁₅₉N₂₅O₃₂S₅
分子量2491.90
MDL号 MFCD00133305
PubChem编号 24894656

属性

存贮条件	储存温度 -20°C
密度	1.1300

描述

应用	带有人类和猪内皮素1序列的合成肽。生物来源是带有相同序列的人内皮素 ETA 和 ETB内皮素受体强效激动剂。诱导缺氧诱导因子1α血管内皮生长因子的生产。
产品介绍	Amino Acid Sequence:Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp [Disulfide Bridges: 1-15; 3-11]. Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells. This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes.
生化机理	Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests. Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
别名	;ET-1 H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH

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