1-萘羟肟酸-分析测试百科网

1-萘羟肟酸

面议

分子式 C11H9NO2 分子量187.20 Beilstein号 EC号 MDL号 MFCD00059546 PubChem编号属性溶解性 DMSO: ≥5 mg/mL //decorateTable('product-attribu

400-6699-117 转1000

耗材描述

溶解性	DMSO: ≥5 mg/mL

生化机理	1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
别名	α-萘羟肟酸;N-Hydroxynaphthalene-1-carboxamide；a-Naphthohydroxamic acid