黄芩素
面议
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分子式 C15H10O5 分子量270.24 Beilstein号 272683 EC号 MFCD00017459 MDL号 MFCD00017459 PubChem编号 24870246 属性 熔点 256-271°C 敏感性 对光和热敏
| 货号 | CAS号 | 价格 | 操作 |
|---|---|---|---|
| B107324-100g | 491-67-8 | 面议 | 询底价 |
| B107324-100mg | 491-67-8 | 面议 | 询底价 |
| B107324-1g | 491-67-8 | 面议 | 询底价 |
| B107324-25g | 491-67-8 | 面议 | 询底价 |
| B107324-5g | 491-67-8 | 面议 | 询底价 |
耗材描述
- 分子式 C15H10O5
- 分子量270.24
- Beilstein号 272683
- EC号 MFCD00017459
- MDL号 MFCD00017459
- PubChem编号 24870246
属性
| 熔点 | 256-271°C |
| 敏感性 | 对光和热敏感 |
| 溶解性 | Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.5480 |
描述
| 应用 | An inhibitor of Ca2+ uptake, 5-LO, and 12-LO |
| 产品介绍 | Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9. |
| 生化机理 | 中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。 |
| 别名 | 三羟黄酮;黄芩苷元;黄芩黄素;黄芩甙元;5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone |
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