耗材描述

• 分子式 C₃₆H₄₅BrN₄O₆
• 分子量709.67
• Beilstein号
• EC号 MFCD00873735
• MDL号 MFCD00873735
• PubChem编号

属性

溶解性	Soluble in DMSO (>2 mg/ml), water (partly), 100% ethanol, and 83% methanol
存贮条件	储存温度-20°C

描述

应用	A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.
生化机理	Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.
别名	;Jaspamide

RTECS	GX7000000
WGK德国	3

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