耗材描述

• 分子式 C₉H₅ClINO
• 分子量305.50
• Beilstein号 153637
• EC号 204-984-4
• MDL号 MFCD00006787
• PubChem编号 24854949

属性

熔点	175°C
溶解性	Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).

描述

应用	A metal chelating ligand that inhibits certain enzymes related to DNA replication.
产品介绍	Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.
别名	奎諾仿;氯碘喹啉;氯碘羟喹;5-氯-7-碘-8-羟基喹啉;Clioqinol; 5-Chloro-8-hydroxy-7-iodoquinoline; Iodochlorhydroxyquin;

Reaxys-RN	153637
标识符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	P301+P310
个人防护设备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS	VC5075000
WGK德国	3
风险声明 (欧洲)	R25
安全声明（欧洲）	S36/37/39;S45
危害码（欧洲）	T

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