耗材描述

• 分子式 C₁₈H₂₀O₅
• 分子量316.35
• Beilstein号
• EC号
• MDL号 MFCD03453309
• PubChem编号

属性

敏感性	对光线敏感
溶解性	DMSO: >10 mg/mL
存贮条件	储存温度-20°C

描述

生化机理

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

别名

(Z)-2-甲氧基-5-(3,4,5-三甲氧基苯乙烯基)苯酚;3'-羟基-3,4,4',5-四甲氧基-顺-芪 ;(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol;3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene;1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,;CA4

Reaxys-RN	4786976
信号词	Danger
危害声明	H301 + H311 + H331-H318
警示性声明	P261-P280-P301 + P310-P305 + P351 + P338-P311
个人防护设备	Eyeshields， Faceshields， Gloves， type P2 (EN 143) respirator cartridges
WGK德国	2

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