C153431-1g考布他汀A4
¥
11999.00
- 阿拉丁
- 生产商
- C153431-1g
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C18H20O5
- 分子量316.35
- Beilstein号
- EC号
- MDL号 MFCD03453309
- PubChem编号
属性
敏感性 | 对光线敏感 |
溶解性 | DMSO: >10 mg/mL |
存贮条件 | 储存温度-20°C |
描述
生化机理 | Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol. |
别名 | (Z)-2-甲氧基-5-(3,4,5-三甲氧基苯乙烯基)苯酚;3'-羟基-3,4,4',5-四甲氧基-顺-芪 ;(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol;3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene;1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,;CA4 |
Reaxys-RN | 4786976 |
信号词 | Danger |
危害声明 | H301 + H311 + H331-H318 |
警示性声明 | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
个人防护设备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
WGK德国 | 2 |
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