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CAS No. : 125697-91-8
MCE 国际站:Lavendustin B
产品活性:Lavendustin B 是 HIV-1 整合酶与 LEDGF/p75 相互作用的抑制剂,IC50 为 94.07 μM。Lavendustin B 是一种具有 ATP 竞争性的 GLUT1 抑制剂,Ki 为 15 µM。Lavendustin B 也是酪氨酸激酶 (tyrosine kinases) 的弱抑制剂。
研究领域:Metabolic Enzyme/Protease | Membrane Transporter/Ion Channel
作用靶点:HIV Integrase | GLUT | Tyrosinase
In Vitro: In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes.
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