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K-7174 dihydrochloride

CAS No. : 191089-60-8

MCE 国际站：K-7174 dihydrochloride

产品活性：K-7174 dihydrochloride 是具有口服活性的 proteasome 和 GATA 的抑制剂。K-7174 dihydrochloride 抑制细胞黏附。K-7174 dihydrochloride 诱导细胞凋亡。K-7174 dihydrochloride 具有抗肿瘤活性，可用于癌症的研究。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Proteasome  |  Apoptosis

In Vitro: K-7174 dihydrochloride (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand.
K-7174 dihydrochloride (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC₅₀ value of 14 μM.
K-7174 dihydrochloride (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC₅₀ value of 9 μM.
K-7174 dihydrochloride (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells.
K-7174 dihydrochloride (2.5-30 μM; 24 h) inhibits the binding activity of GATA.
K-7174 dihydrochloride (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis.

In Vivo: K-7174 dihydrochloride (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α.
K-7174 dihydrochloride (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo.
K-7174 dihydrochloride (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection.

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