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Neticonazole

CAS No. : 130726-68-0

MCE 国际站：Neticonazole

产品活性：Neticonazole 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。Neticonazole 具有抗感染和抗癌作用。

研究领域：Anti-infection

作用靶点：Fungal

In Vitro: Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active exosome biogenesis and secretion inhibitor.

In Vivo: Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.

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