MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 181695-72-7
MCE 国际站:Valdecoxib
产品活性:Valdecoxib 是一种高效的,可口服的,选择性的 COX-2 抑制剂,对 COX-2 和 COX-1 的 IC50 值分别为 5 nM 和 140 μM,可用于关节炎和疼痛的研究。
研究领域:Immunology/Inflammation | Metabolic Enzyme/Protease
作用靶点:COX | Endogenous Metabolite
In Vitro: Valdecoxib (Compound 2) is a highly potent, selective and orally active inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib (10, 100 µM) inhibits LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner. Valdecoxib stimulates VEGF formation via HMEC-1 under inflammatory conditions.
In Vivo: Valdecoxib (Compound 2) shows potent oral activity in an acute antiinflammatory assay (rat carrageenan foot pad edema; ED50 = 10.2 ± 1.4 mg/kg). Valdecoxib also has chronic antiinflammatory activity in the rat adjuvant arthritis model, with an ED50 of 0.032 ± 0.002 mg/kg/day. Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Pyroptosis Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Pancreatic Cancer Compound Library | Food-Sourced Compound Library | Targeted Diversity Library | Rare Diseases Drug Library | Anti-Colorectal Cancer Compound Library | Antidepressant Compound Library | EMA-Approved Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Non-steroidal Anti-Inflammatory Compound Library | Withdrawn Drug Compound Library | Off-patent Drug Library | Highly Selective Inhibitors Library | D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Nicotinamide N-oxide | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Methylmalonic acid | Meloxicam-d3-1 | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | 4-Methylamino antipyrine hydrochloride | Vedaprofen-d3 | Sphingomyelin | Pelubiprofen-13C,d3 | (-)-Jasmonoyl-L-isoleucine | Octanoic acid-d2 | Vardenafil-d5 | N-Acetyllactosamine | D-Arabitol-13C | Imidazole | N-tert-Butyl-α-phenylnitrone-d14 | L-Tartaric acid diammonium | i-Inositol | Tryptophol | L-Aspartic acid
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。