MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Elzovantinib

CAS No. : 2271119-26-5

MCE 国际站：Elzovantinib

产品活性：Elzovantinib (TPX-0022) 是 SRC，MET 和 c-FMS 的口服有效抑制剂, 其对 SRC，MET 和c-FMS 的 IC₅₀ 值分别为 0.12 nM，0.14 nM 和 0.76 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Src  |  c-Met/HGFR  |  c-Fms

In Vitro: Elzovantinib (TPX-0022) causes the suppression of MET autophosphorylation as well as the downstream STAT3, ERK and AKT phosphorylation at IC₅₀ values of around 1-3 nM in SNU-5 and MKN-45 cell lines.

In Vivo: Elzovantinib (TPX-0022; p.o., BID, 13 days) treatment results in an 85% tumor regression and no body weight loss is observed after 21 days treatment in mice.
Elzovantinib (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID and 15 mg/kg, BID, respectively in SCID/Beige mice.
Elzovantinib inhibits MET activity in MKN-45 tumors following oral administration in mice.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Angiogenesis-Related Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Tirbanibulin dihydrochloride  |  AMG-208  |  HIV-IN-6  |  DS-1205b free base  |  Bafetinib  |  c-Met-IN-1  |  Glumetinib  |  Multi-kinase-IN-2  |  CSF1R-IN-12  |  PP2  |  Savolitinib  |  c-Met-IN-11  |  ABN401  |  PP58  |  Foretinib  |  Pexidartinib  |  ENMD-2076 Tartrate  |  Lck-IN-1  |  Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH  |  IACS-9439  |  Bafisontamab  |  MK-2461  |  Ponatinib hydrochloride  |  Dalmelitinib  |  Namilumab  |  TL02-59 dihydrochloride  |  MK-8033 hydrochloride  |  c-Met-IN-12  |  A-770041  |  AZD7507

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。