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Tideglusib

CAS No. : 865854-05-3

MCE 国际站：Tideglusib

产品活性：Tideglusib (NP031112) 是一种不可逆的 GSK-3 抑制剂，抑制 GSK-3β^WT 和GSK-3β^C199A 的 IC₅₀ 分别为5 nM，60 nM。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt

作用靶点：GSK-3

In Vitro: Incubation of both astrocyte and microglial cultures with Tideglusib (NP031112) completely abrogates the induction of TNF-α and COX-2 expression after glutamate treatment. These effects of NP031112 are not caused by a loss of cell viability, because the 24 h exposure of astrocyte and microglial cells to this TDZD does not modify cell viability.

In Vivo: Injection of Tideglusib (NP031112) (50 mg/kg) into the rat hippocampus dramatically reduces kainic acid-induced inflammation, as measured by edema formation using T2-weighted magnetic resonance imaging and glial activation and has a neuroprotective effect in the damaged areas of the hippocampus.

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