MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2406278-81-5
MCE 国际站:OM-153
产品活性:OM-153 是一种有效的,具有口服活性的 tankyrase 抑制剂,对 tankyrase 1 和 tankyrase 2 (TNKS1/2) 的 IC50 分别为 13 nM 和 2 nM。OM-153 抑制基于荧光素酶的 Wnt/β-catenin 信号转导报告基因活性,IC50 值为 0.63 nM。OM-153 抑制 COLO 320DM 中的 Wnt/β-catenin 信号转导和增殖。
研究领域:Cell Cycle/DNA Damage | Epigenetics | Stem Cell/Wnt
作用靶点:PARP | Wnt
In Vitro: OM-153 shows picomolar IC50 inhibition (0.63 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay, no off-target liabilities, overall favorable absorption, distribution, metabolism, and excretion (ADME) properties, and an improved pharmacokinetic profile in mice.
OM-153 decreases cell growth in COLO 320DM cells with a GI50 value of 10 nM and a GI25 value of 2.5 nM (concentrations resulting in 50% and 25% growth inhibition, respectively), while cell growth in RKO cells was insubstantially affected by the treatment.
OM-153 inhibits WNT/β-catenin, YAP, and MYC signaling and shows an antiproliferative fffect in human cancer cell lines.
In Vivo: OM-153 (0.1-10 mg/kg; p.o.; twice daily; for 34 days) reduces WNT/β-catenin signaling and tumor progression in COLO 320DM colon carcinoma xenografts.
OM-153 potentiates anti-PD-1 immune checkpoint inhibition and antitumor effect in a B16-F10 mouse melanoma model.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Antihypertensive Compound Library | iRucaparib-AP6 | Rucaparib monocamsylate | AZD-2461 | RBN-2397 | FzM1 | Rucaparib acetate | Niraparib tosylate | Pamidronic acid | Olaparib-d8 | G007-LK | Basroparib | Fz7-21 | Anticancer agent 64 | UPF 1069 | Talazoparib tosylate | BPA-B9 | MSC2504877 | NSC668036 | JW67 | Ipafricept | Ipivivint | WIC1 | Oxychlororaphine | PROTAC PARP1 degrader | 5,7-Dihydroxychromone | JW74 | IQ 1 | Heparan Sulfate | PARP1-IN-5 | L-Quebrachitol
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。