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Diflunisal

CAS No. : 22494-42-4

MCE 国际站：Diflunisal

产品活性：Diflunisal (MK-647) 是一种水杨酸盐衍生物，具有非甾体抗炎和尿酸舒缓性能，可单独用作止痛剂和类风湿关节炎患者。Diflunisal是环氧合酶 (COX) 的抑制剂。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vivo: Administration of increasing doses of Diflunisal to rats shows that the effect of the dose on the pharmacokinetics of Diflunisal is quite complicated. The plasma concentrations of Diflunisal decline exponentially with time, albeit with a half-life that increases with increasing dose. The CL_P is reduced considerably when the dose increases from 3 to 10 mg/kg and then remains relatively constant over the dose range of 10 to 60 mg/kg. Diflunisal has been shown to be highly bound to rat plasma protein and dependent on concentration. The fraction of unbound Diflunisal is increased about 10-fold over the concentration range of 5 to 300 μg/mL. Diflunisal exhibits activity after oral administration with potency about 25 times greater than that of aspirin, about 3 times that of glafenine and twice that of zomepirac.

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